Recombinant Paraponera clavata Delta-paraponeritoxin-Pc1a CSB-BP340426PCP
Specifications
| 20ug / 100ug / 500ug price = 100ug |
Alternative Name(s):
Pac-TX
Species: (Organism)
Paraponera clavata (Bullet ant) (Izuela)
Gene Names:
N/A
Tag info:
N-terminal 6xHis-tagged
Target Protein AA Sequence:
FLPLLILGSLLMTPPVIQAIHDAQR
Expression Region:
1-25aa
Subcellular Location:
Secreted
Tissue Specificity:
Expressed by the venom gland.
Protein Length:
Full Length
Pathway:
Mol. Weight:
3.7 kDa
Purity:
Greater than 90% as determined by SDS-PAGE.
Form:
Liquid or Lyophilized powder
Buffer:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Research Areas:
Others
Function:
Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.
Involvement in disease:
Relevance:
Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.
Reconstitution:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Protein Families:
Reference:
"Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)." Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O. Comp. Biochem. Physiol. 99C:481-486(1991)
