Background:

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.

Classification:

Primary antibody

Alternative names:

NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide

Species reactivity:

Human

Host:

Mouse

Isotype:

IgG

Immunogen:

Synthetic peptide corresponding to aa (Glu-Pro-Leu-Gln-Glu-Ser-Pro-Arg-Pro-Thr-Gly-Val-Trp-Cys) of human BNP, conjugated to KLH.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for one year

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