Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
Bioworld Technology is one of the leading phospho-antibody manufacturers. They have produced over 500 phospho-antibodies for AKT, AMPK, GSK, STAT pathways. The peptides corresponding to each phospho-antibody have also been listed to help scientists.
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RecombinantIL-19,Mouse BK0093

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Specifications

size	10μg / 50μg / 1mg

Source:

Escherichia coli.

Molecular Weight:

17.7 kDa, observed by non-reducing SDS-PAGE.

Purity:

> 95% by SDS-PAGE analysis.

Biological activity:

ED50 < 50 ng/mL, measured by a cell proliferation assay using MCF-7 cells, corresponding to a specific activity of > 2× 10ˆ4 units/mg.

AA Sequence:

MLRRCLISV DMRLIEKSFH EIKRAMQTKD TFKNVTILSL ENLRSIKPGD VCCMTNNLLT FYRDRVFQDH QERSLEVLRR ISSIANSFLC VQKSLERCQV HRQCNCSQEA TNATRIIHDN YNQLEVSSAA LKSLGELNIL LAWIDRNHLE TPAA

Endotoxin:

< 0.2 EU/μg, determined by LAL method.

Formulation:

Lyophilized after extensive dialysis against 50mM acetic acid.

Background:

Interleukin-19 (IL-19) is a cytokine belonging to the interleukin family. Structurally, IL-19 is grouped into the IL-10 sub-family, which also includes IL-20, IL-22, IL-24, and IL-26. In contrast to IL-10, which exists as a homodimer, IL-19 is stable and active as a monomer in vivo. IL-19 functions through the receptor complex composed of IL-20 Receptor α and IL-20 Receptor β, which is also utilized by IL-20 and IL-24. IL-19 is produced by active monocytes and stimulated synergistically by IL-17 and IL-13. The functions of IL-19 are to promote the development and function of Th2 cells and to enhance the production of Th2 cytokines. IL-19 is implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis. Recombinant mouse Interleukin-19 (rmIL-19) produced in E.coli is a single non-glycosylated polypeptide chain containing of153 amino acids. A fully biologically active molecule, rmIL-19 has a molecular mass of 17.7 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

Usage:

This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Reconstitution:

Reconstituted in 50 mM acetic acid at 50 μg/mL.

Storage:

Lyophilized recombinant mouse Interleukin-19 (rmIL-19) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIL-19 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.